منابع مشابه
LKB1 and AMPK differentially regulate pancreatic b-cell identity
Fully differentiated pancreatic b cells are essential for normal glucose homeostasis in mammals. Dedifferentiation of these cells has been suggested to occur in type 2 diabetes, impairing insulin production. Since chronic fuel excess (“glucotoxicity”) is implicated in this process, we sought here to identify the potential roles in b-cell identity of the tumor suppressor liver kinase B1 (LKB1/ST...
متن کاملThe B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis.
Pax5 controls the identity and development of B cells by repressing lineage-inappropriate genes and activating B-cell-specific genes. Here, we used genome-wide approaches to identify Pax5 target genes in pro-B and mature B cells. In these cell types, Pax5 bound to 40% of the cis-regulatory elements defined by mapping DNase I hypersensitive (DHS) sites, transcription start sites and histone modi...
متن کاملThe B cell identity factor Pax5 regulates distinct transcriptional programs in early and late B lymphopoiesis
As you can see, the referees appreciate that the analysis provides new insight into Pax5-mediate gene regulation during B cell development and are overall supportive of publication here. They raise a number of specific concerns that shouldn't involve too much additional work to address. What is also needed is a better understanding of how Pax5 binds distinct targets in pro-B and mature B cells....
متن کاملShedding light on cell cycle control by T and B lymphocytes
T lymphocytes are an important element of the adaptive immune response. While normally quiescent, T cells can replicate rapidly to build an army of antigenspecific cells in only a few days following an immune challenge. Many of the cells created are short-lived and die within the first 2 weeks, whereas other cells return to a quiescent long-lived state and serve as memory cells capable of faste...
متن کاملSerological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1
By three criteria, we have demonstrated that B cell stimulatory factor (BSF-1) and B cell differentiation factor (BCDF-gamma) are the same lymphokine. Highly purified preparations of high performance liquid chromatography-purified or affinity-purified BSF-1 had BCDF-gamma activity but not BCDF-mu activity. A monoclonal anti-BSF-1 antibody coupled to Sepharose depleted both BSF-1 and BCDF-gamma ...
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ژورنال
عنوان ژورنال: Immunity
سال: 2006
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2006.03.005